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《环境科学与工程前沿（英文）》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1501-8
• Oxidation of methotrexate by high-valent metal-oxo species was first explored.
关键词： Anticancer drugs High-valent metal-oxo species Oxidation kinetics Reaction mechanisms Multi-endpoint toxicity
《化学科学与工程前沿（英文）》 2022年 第16卷 第1期 页码 112-120 doi: 10.1007/s11705-021-2075-5
关键词： fluorescent drug lysosomal anticancer zebrafish nude-mouse tumour imaging
Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection
Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang
《医学前沿（英文）》 2021年 第15卷 第3期 页码 404-415 doi: 10.1007/s11684-021-0834-9
关键词： Zika virus clinical drugs ZIKV inhibitors antivirals repurposing
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
《医学前沿（英文）》 doi: 10.1007/s11684-023-1037-3
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
null
《医学前沿（英文）》 2012年 第6卷 第1期 页码 67-78 doi: 10.1007/s11684-012-0176-8
Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, recent studies have shown that antiangiogenic therapy has transient and insufficient efficacy, resulting in tumor recurrence in patients after several months of treatment. Blockage of blood and oxygen supplies creates a hypoxic and acidic microenvironment in the tumor tissues, which fosters tumor cells to become more aggressive and metastatic. In 2001, Jain proposed tumor vascular normalization as an alternative approach to treating cancers based on the pioneering work on tumor blood vessels by several other researchers. At present, normalizing the disorganized tumor vasculature, rather than disrupting or blocking them, has emerged as a new option for anticancer therapy. Preclinical and clinical data have shown that tumor vascular normalization using monoclonal antibodies, proteins, peptides, small molecules, and pericytes resulted in decreased tumor size and reduced metastasis. However, current tumor vascular normalizing drugs display moderate anticancer efficacy. Accumulated data have shown that a variety of vasculogenic/angiogenic tumor cells and genes play important roles in tumor neovascularization, growth, and metastasis. Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor vascular normalization. To this end, the combination of antiangiogenic drugs with tumor vascular normalizing therapeutics, as well as the integration of Western medicine with traditional Chinese medicine, may provide a good opportunity for discovering novel tumor vascular normalizing drugs for an effective anticancer therapy.
关键词： angiogenesis vasculogenesis neovascularization tumor vasculature normalization traditional Chinese medicine
Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines
Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG
《农业科学与工程前沿（英文）》 2015年 第2卷 第4期 页码 335-340 doi: 10.15302/J-FASE-2015079
关键词： b-pinene nopinone synthesis 2-amino-3-cyanopyridine anticancer
Siyu Chen, Lee Blaney, Ping Chen, Shanshan Deng, Mamatha Hopanna, Yixiang Bao, Gang Yu
《环境科学与工程前沿（英文）》 2019年 第13卷 第4期 doi: 10.1007/s11783-019-1143-2
Specific second-order rate constants were determined for 5-FU and CAP with ozone. Reaction sites were confirmed by kinetics, Fukui analysis, and products. The olefin moiety was the main ozone reaction site for 5-FU and CAP. Carboxylic acids comprised most of the residual TOC for 5-FU. Ozonation removed the toxicity associated with 5-FU and products but not CAP.
关键词： Ozone 5-fluorouracil Capecitabine Hydroxyl radicals Chemotherapy agents Toxicity
Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu
《环境科学与工程前沿（英文）》 2019年 第13卷 第4期 doi: 10.1007/s11783-019-1140-5
We developed a method for determining 11 abused drugs in water and sediment. METH and EPH were the dominant drugs in water and sediment in Beiyunhe River. Abuse drugs in Beiyunhe River were mainly from hospitals and sewage effluents. Abused drugs in the water would not impair the aquatic ecosystem biologically.
关键词： Drugs of abuse Occurrence Distribution Urban river Environmental risk
Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)
《医学前沿（英文）》 2022年 第16卷 第5期 页码 815-826 doi: 10.1007/s11684-021-0891-0
关键词： B-cell lymphoma oral drug targeted therapy immunotherapy COVID-19 pandemic
Vaibhav Mundra, Ram I. Mahato
《化学科学与工程前沿（英文）》 2014年 第8卷 第4期 页码 387-404 doi: 10.1007/s11705-014-1457-3
关键词： nanocarrier cellular uptake endosomal release nucleic acid drug
Telomeric impact of conventional chemotherapy
null
《医学前沿（英文）》 2013年 第7卷 第4期 页码 411-417 doi: 10.1007/s11684-013-0293-z
The increased level of chromosome instability in cancer cells, leading to aneuploidy and gross chromosomal rearrangements, is not only a driving force for oncogenesis but also can be the Achille’s heel of the disease since many chemotherapies (CT) kill cells by inducing a non-tolerable rate of DNA damage. A wealth of published evidence showed that telomere stability can be more affected than the bulk of the genome by several conventional antineoplasic drugs. These results raise the interesting possibility that CT with genotoxic drugs preferentially target telomeres. In agreement with this view, accelerated shortening of telomere length has been described in blood lineage cells following high-dose CT (stem cell transplantation) or non-myeloablative CT. However, almost nothing is known on the consequences of this shortening in terms of telomere stability, senescence and on the development of second cancers or post-treatment aging-like syndromes in cancer survivors (cognitive defect, fertility impairment, etc.). In this article, we propose: (1) telomeres of cancer cells are preferential genomic targets of chemotherapies altering chromosome maintenance; (2) telomere functional parameters can be a surrogate marker of chemotherapy sensitivity and toxicity; (3) the use of anti-telomere molecule could greatly enhance the sensitivity to standards chemotherapies.
关键词： telomere antineoplasic drugs conventional chemotherapies
null
《医学前沿（英文）》 2012年 第6卷 第1期 页码 22-34 doi: 10.1007/s11684-012-0178-6
Stroke is a personal, familial, and social disaster. It is the third cause of death worldwide, the first cause of acquired disability, the second cause of dementia, and its cost is astronomic. The burden of stroke is likely to increase given the aging of the population and the growing incidence of many vascular risk factors. Prevention of stroke includes—as for all other diseases—a “mass approach” aiming at decreasing the risk at the society level and an individual approach, aiming at reducing the risk in a given subject. The mass approach is primarily based on the identification and treatment of vascular risk factors and, if possible, in the implementation of protective factors. These measures are the basis of primary prevention but most of them have now been shown to be also effective in secondary prevention. The individual approach combines a vascular risk factor modification and various treatments addressing the specific subtypes of stroke, such as antiplatelet drugs for the prevention of cerebral infarction in large and small artery diseases of the brain, carotid endarterectomy or stenting for tight carotid artery stenosis, and oral anticoagulants for the prevention of cardiac emboli. There is a growing awareness of the huge evidence-to-practice gap that exists in stroke prevention largely due to socio-economic factors. Recent approaches include low cost intervention packages to reduce blood pressure and cheap “polypills” combining in a single tablet aspirin and several drugs to lower blood pressure and cholesterol. Polypill intake should however not lead to abandon the healthy life-style measures which remain the mainstay of stroke prevention.
关键词： stroke prevention vascular risk factors cerebral infarction cerebral hemorrhage anti-thrombotic drugs carotid endarterectomy
Factors related to compliance with oral analgesic treatment of inpatients with chronic pain
null
《医学前沿（英文）》 2015年 第9卷 第3期 页码 374-379 doi: 10.1007/s11684-015-0411-1
This study aimed to determine the relationship between the different factors of analgesic therapy and the compliance of chronic pain inpatients. We prospectively investigated 100 consecutive inpatients with non-cancer chronic pain who were hospitalized to receive oral analgesic treatment in the Pain Department of West China Hospital from May 2013 to October 2013. Patients who completed the treatment plan were recorded as good compliance, whereas patients who partly completed or even refused the treatment were recorded as moderate or non-compliance, respectively. A total of 73 (73.7%), 17 (17.1%), and 9 (9.2%) patients showed good, moderate, and non-compliance, respectively. Univariate analyses showed significantly better compliance among farmers, patients educated in college or above, with family income of<3000 CNY, and with severe or moderate pain than those employed and unemployed (P=0.02), patients educated below college (P=0.013), with family income of≥3000 CNY (P=0.025), and with mild pain (P<0.001), respectively. Logistic regression analysis showed that the family income of≥3000 CNY (OR: 2.50, 95%CI: 1.65–4.51, P=0.021) and mild pain (OR: 1.27, 95%CI: 1.03–3.31, P=0.016) were associated with moderate or non-compliance with oral analgesic treatment. In conclusion, the low compliance with oral treatment of analgesics was found in Chinese inpatients with chronic pain and compliance was negatively associated with family income and degree of pain of patients.
《化学科学与工程前沿（英文）》 2023年 第17卷 第10期 页码 1503-1515 doi: 10.1007/s11705-022-2294-4
关键词： insoluble drugs polymer inhibition crystallization crystal growth kinetics DFT calculations
标题 作者 时间 类型 操作
Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate in water
期刊论文
Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging
期刊论文
Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection
Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang
期刊论文
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
null
期刊论文
Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines
Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG
期刊论文
Ozonation of the 5-fluorouracil anticancer drug and its prodrug capecitabine: Reaction kinetics, oxidation
Siyu Chen, Lee Blaney, Ping Chen, Shanshan Deng, Mamatha Hopanna, Yixiang Bao, Gang Yu
期刊论文
Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban
Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu
期刊论文
Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)
期刊论文
nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs
Vaibhav Mundra, Ram I. Mahato
期刊论文
Factors related to compliance with oral analgesic treatment of inpatients with chronic pain
null
期刊论文
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